In 1953, the province's first three-year textile engineering section was divided into two groups: textile engineering and textile chemistry.
On August 1, 1993, the school was restructured into the "National Taipei Institute of Technology." The four-year textile engineering department was established and divided into two groups, weaving and textile chemistry.
On August 1, 1997, the school was restructured into "National Taipei University of Technology". The department was renamed as textile engineering.
In 2001, the organic polymer group of the Institute of Engineering Science and Technology enrolled doctoral students.
On August 1, 2002, it was renamed the Department of Molecular Science and Engineering.